Mixed Ligand Copper (II) Complex with Isoniazid and Pyrazinamide

The fact that the pharmacological action of certain drugs was due to the formation of chelates with essential or trace metal ions of biological significance prompted many research workers all over the world to investigate the structural features of the metal chelates of drug substances both in solid state and in solution. So it was considered interesting and useful to study the metal complexes of drugs using various physicochemical methods. It is proposed to study the metal binding characteristics of some selected pharmaceuticals mentioned below. Isoniazid, a common antituberculosis drug, was shown to form complexes with metal ions like, Fe, Co 2+ , Ni 2+ , Cu 2+ and Zn 2+ . (1) . Isoniazid was shown to form both 1:1 and 1:2 complexes with copper, binding through oxygen and amino nitrogen. (2-3) Pyrazinamide, another antituberculosis drug was reported to form metal complexes of the type MX2, 4L where M= Co(II), Ni(II), Cu(II) and X = Cl 1 , Br  , I  . Besides thermal and spectral studies of these complexes, ESR spectral study was also made for the copper complex. (4) Nickel was also shown to form neutral 1:2 complex with pyrazinamide. Keyword: Isoniazid,Pyrazinamide